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Aerotek Protein Biophysics Scientist in San Carlos, California


Our client is studying a large number of antibodies and related molecules for use in our proteomics platform. We are looking for a scientist to perform and manage the analysis and characterization of these antibodies. Antibody analysis will include a variety of techniques including ELISA assays, kinetic binding constant determination (SPRi, Biacore, ITC etc), and profiling to define binding antigens and non-binding antigens in high or moderate-throughput format.

There are also projects involving antibody engineering and chemical modification. The candidate will work with that team to optimize engineering goals, methods (phage display, rational design, computational design), screening workflows, and characterization of antibody variants.

Role and Responsibilities

Develop and execute antibody analysis (workflows, multiparameter analysis) for a number of antibodies and related molecules

Characterize binding and non-binding interaction affinities under a range of conditions relevant for our proteomics assay

Characterize the thermodynamic and kinetic constants of antigen/antibody interactions (SPR, ITC, BLI, MST)

Be an integral member of an antibody engineering team focused on developing antibodies to meet specific requirements for our proteomics assay

Work cross-functionally with other research teams to align antibody performance with proteomics assay needs


antibody, ELISA, Protein purification, Protein expression

Additional Skills & Qualifications:

Qualifications and Education Requirements

A minimum of 3 years of experience characterizing, engineering, or studying multiple antibodies

Ability to manage, prioritize and analyze complex workflows for large numbers of molecules

Expertise in antibody/antigen binding analysis and characterization using one or more standard instrumental methods

Experience working in a dynamic research environment with rapidly evolving needs and specifications

Ability to build workflows for others to execute

Effectively present and report your findings internally and at scientific meetings

Experience Level:

Expert Level

About Aerotek:

We know that a company's success starts with its employees. We also know that an individual's success starts with the right career opportunity. As a Best of Staffing® Client and Talent leader, Aerotek's people-focused approach yields competitive advantage for our clients and rewarding careers for our contract employees. Since 1983, Aerotek has grown to become a leader in recruiting and staffing services. With more than 250 non-franchised offices, Aerotek's 8,000 internal employees serve more than 300,000 contract employees and 18,000 clients every year. Aerotek is an Allegis Group company, the global leader in talent solutions. Learn more at Aerotek.com.

The company is an equal opportunity employer and will consider all applications without regards to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.