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Responsibilities

Two Post-Doctoral Research Fellow positions are available in the Division of Nephrology & Hypertension and Department of Physiology & Biomedical Engineering. The Post-Doctoral Research Fellows will work on research projects focusing on the molecular mechanisms regulating intestinal oxalate transport, with special emphasis on SLC26A6 (an anion exchanger with an essential role in intestinal oxalate secretion), and how this regulation might pertain to the risk of hyperoxalemia, hyperoxaluria and related disorders (including kidney stones). One of the main projects is about evaluating the therapeutic effects of Oxalobacter formigenes (a probiotic gut bacterium)-derived novel proteins (including OxBSel1-2 and OxBSel1-14) and OxBSel1-14-derived small peptides (P8 and P9) as potential novel therapeutics agents for hyperoxalemia, hyperoxaluria, and related disorders (including kidney stones). This include evaluating the therapeutic effects of optimized (through structural modifications) P8 and P9, P8 and P9-peptide loaded nanoparticles, and Lactococcus lactis expressing P8, P9, OxBSel1-2, and OxBSel1-14 in hyperoxaluric and hyperoxalemic mice. Another project is about evaluating the therapeutic effects of small molecules drugs already in clinical use in humans as potential novel therapeutics agents for hyperoxalemia, hyperoxaluria, and related disorders. Other projects include 1. Identifying P8 and P9 critical amino acids and signaling pathways, as well as the receptor(s) by which they stimulate intestinal oxalate transport. 2. Pathogenesis of obesity- and IBD-associated hyperoxaluria, including the potential role of the gut microbiome.

Dr. Hassan’s research has obtained several prestigious awards/grants, including an NIH fast-track STTR grant and an NSF Phases I & II STTR grants to achieve further pre-clinical milestones towards commercialization of these novel peptides. Substantial resources are in place for this work. Potential for independent work and publications exists.

Qualifications

Must have a Ph.D., M.D., or equivalent doctoral degree in a field deemed relevant by the program. Research Fellow is appropriate for individuals who have completed no more than one prior postdoctoral fellowship, at Mayo Clinic or elsewhere.

• A PhD or MD/PhD degree with a background in cell biology, molecular biology, or a similar field. MDs with extensive wet lab experience will be considered.

• Prior experience with animals is highly preferred – training can be provided.

• Experience with basic molecular biology and biochemical techniques.

• Desire to learn new skills and perform meticulous work.

• Ability to communicate both verbally and written.

• Experience with writing and publishing peer-reviewed manuscripts.

Exemption Status

Exempt

Compensation Detail

Education, experience and tenure may be considered along with internal equity when job offers are extended.

Benefits Eligible

Yes

Schedule

Full Time

Hours/Pay Period

80

Schedule Details

M-F Days

Weekend Schedule

As needed

International Assignment

No

Site Description

Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is. (https://jobs.mayoclinic.org/alllocations)

Affirmative Action and Equal Opportunity Employer

As an Affirmative Action and Equal Opportunity Employer Mayo Clinic is committed to creating an inclusive environment that values the diversity of its employees and does not discriminate against any employee or candidate. Women, minorities, veterans, people from the LGBTQ communities and people with disabilities are strongly encouraged to apply to join our teams. Reasonable accommodations to access job openings or to apply for a job are available.

Recruiter

Victoria Esteves

Equal opportunity

As an Affirmative Action and Equal Opportunity Employer Mayo Clinic is committed to creating an inclusive environment that values the diversity of its employees and does not discriminate against any employee or candidate. Women, minorities, veterans, people from the LGBTQ communities and people with disabilities are strongly encouraged to apply to join our teams. Reasonable accommodations to access job openings or to apply for a job are available.