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Responsibilities

The Department of Molecular Medicine is seeking a post-doctoral research fellow in the lab of Dr. Patricia Devaux.

The main focus of Dr. Devaux’s lab is the development of safe and efficient negative strand RNA virus-based vectors for gene therapy and cellular reprogramming. This vector is based on the measles virus vaccine, one of the safest vaccines in the World. The group previously developed the measles virus into a single-cycle vector and expressed the four reprogramming factors identified as essential to reprogram somatic cells into induced pluripotent stem cells (iPSCs). The lab aims to develop new therapies for hematological disorders, cancer immunotherapy, and Diabetes based on integration-free measles vectors.

The recruited scientist will:

• Be involved in developing new Measles vectors for gene and cell therapy for hematological disorders.

• Collaborate with other group members to carry out the experimental work.

• Oversee the day-to-day activity of their project and report progress to Dr. Devaux.

• Be responsible for the proper collection, storage, record of their work and analysis of their data for presentation.

Previous research experiences in cellular biology and tissue culture are required, and expertise in the culture of iPSC or gene editing is highly desirable. Experience in virology is a plus but not required. Strong oral and written communication skills and the ability to work in a team are also requirements. The candidate will need a strong work ethic and will be someone with aspirations to teach other scientists.

A Zoom interview and research presentation are required for consideration.

Applicants should submit a CV, including a complete list of publications, a cover letter detailing how their expertise and training align with the description described above, a brief career plan, and the name and contact information for three references.

Additional information on Measles reprogramming or Dr. Devaux’s laboratory can be found in:

Wang et al 2019 Gene Therapy, 26(5): 151-164

Rallabandi et al. 2022, Molecular Therapy-Methods and Clinical Development - 24: 48-61

https://www.mayo.edu/research/faculty/devaux-patricia-ph-d/bio-00027780

A Research Fellow at Mayo Clinic is a temporary position intended to provide training and education in research. Individuals will train in the research program of a Mayo Clinic principal investigator. Qualified individuals will demonstrate the potential for research as evidenced by their training and peer-reviewed publications and should become competitive for national research grants. Proof of English proficiency is required for J-1 Short-Term Scholars, Research Scholars, Professors, Specialists, and Student Interns sponsored by Mayo Clinic.

The following is required for completeness of application:

• Current curriculum vitae with bibliography

• Proof of doctoral degree (copy of diploma or final transcript with English translation, if applicable) or a letter from your university's Registrar office indicating you have fulfilled all doctoral program requirements and are eligible to graduate.

Please also be prepared that you may be asked to provide three letters of recommendation to the hiring PI prior to an interview.

Qualifications

Must have a Ph.D., M.D., or equivalent doctoral degree in a field deemed relevant by the program. Research Fellow is appropriate for individuals who have completed no more than one prior postdoctoral fellowship, at Mayo Clinic or elsewhere.

Exemption Status

Exempt

Compensation Detail

Education, experience and tenure may be considered along with internal equity when job offers are extended.

Benefits Eligible

Yes

Schedule

Full Time

Hours/Pay Period

80

International Assignment

No

Site Description

Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is. (https://jobs.mayoclinic.org/alllocations)

Affirmative Action and Equal Opportunity Employer

As an Affirmative Action and Equal Opportunity Employer Mayo Clinic is committed to creating an inclusive environment that values the diversity of its employees and does not discriminate against any employee or candidate. Women, minorities, veterans, people from the LGBTQ communities and people with disabilities are strongly encouraged to apply to join our teams. Reasonable accommodations to access job openings or to apply for a job are available.

Recruiter

Beza Dejene

Equal opportunity

As an Affirmative Action and Equal Opportunity Employer Mayo Clinic is committed to creating an inclusive environment that values the diversity of its employees and does not discriminate against any employee or candidate. Women, minorities, veterans, people from the LGBTQ communities and people with disabilities are strongly encouraged to apply to join our teams. Reasonable accommodations to access job openings or to apply for a job are available.