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Responsibilities

The Beyder Laboratory at Mayo Clinic's world-renowned Enteric Neuroscience Program (ENSP) is seeking a motivated post-doctoral fellow to join our dynamic team. We focus on cutting-edge research in the physiology of the gut-brain axis and enteric nervous system. Our mission is to uncover the fundamental mechanisms of mechanosensing and mechanotransduction in the gut and leverage these discoveries into answers to key questions in gut-brain health and disease.

Who We Are . Led by Dr. Arthur Beyder, a physician-scientist, our lab thrives in the collaborative environment of ENSP, working with a diverse group of leading ENSP and world-wide investigators. We are committed to exploring the gut's ability to sense mechanical forces and what that means for health and disease. Inspired by the 2021 Nobel Prize in Physiology or Medicine awarded for discoveries of mechanogated ion channels We address questions like – does the gut feel touch? Our research is published in top journals such as eLife, Gastroenterology, PNAS, and Cell, and we are backed by prestigious NIH grants, including the New Innovator Award.

Research Focus . You will lead cutting-edge NIH-funded projects centered on mechano-electrophysiology of tissues, cells and molecules. You’ll use state-of-the-art techniques and develop novel ones, like optogenetics and CRISPR-screens, pressure-patch-clamp, whole-cell electrophysiology with various mechanical stimuli, and mechanosensitive ion channel biophysics to explore the fascinating realm of mechanosensitive ion channels. Expect to integrate your findings with advanced imaging approaches, including calcium signaling assays and mechanobiology models, organoids, and patient-derived tissues. Your research will be at the heart of uncovering how these channels contribute to gut mechanobiology.

Qualifications . A Ph.D. with electrophysiology experience in physiology, neuroscience, biophysics, or a related field is preferred but not required. Most importantly, we are looking for passion for scientific discovery, problem-solving skills, and a drive for excellence and independence.

Why Join Us? The Beyder Lab is not just a place to work—it’s a place to grow, discover, and make a difference! With access to top-notch resources, mentorship, and training, you’ll have every opportunity to advance your career. Present your findings at major conferences, engage with the global research community, and mentor the next generation of scientists. We’re here to support your journey toward becoming an independent and impactful researcher.

Lab Culture . We believe in the power of teamwork, diversity, and celebrating our wins together. Expect a fun, inclusive atmosphere with regular lab retreats, social events, and shared learning experiences.

Contact. Art Beyder at beyder.arthur@mayo.edu or @BeyderLab on social media for more information.

Some examples of electrophysiology in our work : Alcaino et al. PNAS. A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release | PNAS (https://www.pnas.org/doi/abs/10.1073/pnas.1804938115?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed) Single-cell mechano-electrophysiology . Treichel and Finholm et al. Gastroenterology. Specialized Mechanosensory Epithelial Cells in Mouse Gut Intrinsic Tactile Sensitivity - ScienceDirect (https://www.sciencedirect.com/science/article/pii/S0016508521036647?via%3Dihub) Optogenetics+single-cell electrophysiology. Strege et al. eLife. Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel | eLife (https://elifesciences.org/articles/79271) . Single channel recordings with pressure clamp.

Qualifications

Must have a Ph.D., M.D., or equivalent doctoral degree in a field deemed relevant by the program. Research Fellow is appropriate for individuals who have completed no more than one prior postdoctoral fellowship, at Mayo Clinic or elsewhere.

Exemption Status

Exempt

Compensation Detail

Education, experience and tenure may be considered along with internal equity when job offers are extended.

Benefits Eligible

Yes

Schedule

Full Time

Hours/Pay Period

80

Schedule Details

Monday-Friday

Weekend Schedule

as needed

International Assignment

No

Site Description

Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is. (https://jobs.mayoclinic.org/alllocations)

Affirmative Action and Equal Opportunity Employer

As an Affirmative Action and Equal Opportunity Employer Mayo Clinic is committed to creating an inclusive environment that values the diversity of its employees and does not discriminate against any employee or candidate. Women, minorities, veterans, people from the LGBTQ communities and people with disabilities are strongly encouraged to apply to join our teams. Reasonable accommodations to access job openings or to apply for a job are available.

Recruiter

Kara Schott

Equal opportunity

As an Affirmative Action and Equal Opportunity Employer Mayo Clinic is committed to creating an inclusive environment that values the diversity of its employees and does not discriminate against any employee or candidate. Women, minorities, veterans, people from the LGBTQ communities and people with disabilities are strongly encouraged to apply to join our teams. Reasonable accommodations to access job openings or to apply for a job are available.