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ROLE SUMMARY:

As a Principal Scientist Downstream R&D you will contribute to downstream process development for various vaccine programs. You will work closely with the Senior Principal Scientist/Director to develop and apply interdisciplinary approaches to improve purification and characterization of the mRNA Drug Substance (DS) for the development of next-generation RNA vaccine candidates. You will be recognized as a technical expert and a significant scientific contributor. With your deep knowledge of the discipline, you will regularly contribute at the vaccine development meetings and can represent the department on multidisciplinary teams. You will also undertake mentoring activities to guide team members. With your innovative scientific acumen, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class mRNA-based vaccines to patients around the world.

POSITION RESPONSIBILITIES

• Lead the multi-step design, planning and execution of analytical strategies, methods and instrumentation to purify and characterize the mRNA Drug Substance (DS).

• Develop continuous downstream process for drug substance.

• Mentor junior scientists' research activities and provide technical guidance when necessary.

• Collaborates with colleagues and subject matter experts to assess the most appropriate analytical approach to support project activities, including use of computational predictive tools, modelling software and data visualization tools where appropriate.

• Through effective leadership, communication and collaboration with multidisciplinary team members, this colleague will have the opportunity to lead and be responsible for several projects, helping teams devise effective strategies for analytical requirements and controls.

• The candidate must collaborate with, mentor peers, and effectively interact with colleagues at all levels of the organization.

• Author relevant sections of vaccine technical report documents in support for interdepartmental technology and method transfer. They will also prepare technical reports, critically review data, and may evaluate new instrumentation and analytical techniques/approaches.

• Proficient with a wide variety of software and information systems and the curiosity and passion to continue learning in a dynamic environment.

ORGANIZATIONAL RELATIONSHIPS

• This colleague will interact with Bioprocess Fermentation, Analytical, and Formulation Development groups to support downstream process development and in-process sample analysis activities.

RESOURCES MANAGED

Financial Accountability

• The incumbent advises the supervisor of the equipment and consumables required to accomplish the work.

Supervision

• The incumbent will have supervisory responsibilities.

EDUCATION AND EXPERIENCE

• PhD degree in Biochemistry, Analytical Chemistry or related field, with at least 2+ years relevant downstream industry experience

• Extensive hands-on experience and strong background in chromatography and filtration.

• Prior experience with bio-process downstream development.

• Experience with nucleic acid or protein purification and characterization including FPLC, HPLC, UF/DF, UV/Vis, SDS-PAGE, and/or Fragment Analyzer/Tape station.

• Understanding of critical quality attributes of drug substance.

• Prior experience with tech transfer to manufacturing site is preferred.

• Experience with continuous processing is preferred.

• Exemplary people skills and demonstrable leadership behaviors.

• Excellent problem-solving skills.

• Demonstrated technical writing and presentation skills.

TECHNICAL SKILLS REQUIREMENTS

• Knowledge and ability to independently design, plan, and execute purification / recovery activities.

• Independently analyze and provide conclusions regarding experimental data generated

PHYSICAL/MENTAL REQUIREMENTS

• Conducts all activities and makes decisions that are in accordance with Company policies & SOPs, Pfizer Values, & global regulatory guidelines (including cGMP/cGLP/cGCP), environmental guidelines, as appropriate, etc.

Work Location Assignment:On Premise with relocation assistance available

The annual base salary for this position ranges from $99,900.00 to $166,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development