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ROLE SUMMARY

Pfizer's Oncology Research Unit (ORU) unit in La Jolla, California, is seeking a Senior Principal Scientist (PhD) to join the Post-CAN Research group focused on translating basic discoveries in the field of cancer cell biology into novel therapeutics.

The Senior Principal Scientist will lead preclinical research with a collaborative team of motivated and scientifically rigorous scientists to advance our clinical and pre-clinical drug programs in the field of cancer cell biology. Our ideal candidate will have a strong background in leading translational research on oncology cell signaling and cell cycle assets and employing state-of-the art approaches to develop deeper understanding of their mechanism of action. The candidate will lead efforts to translate basic research findings into therapeutic strategies, utilizing pharmacological and genetic approaches to investigate target biology, patient stratification strategies, mechanisms of resistance and combination strategies. The successful candidate will demonstrate a proven track record of scientific leadership and productivity as evidenced by impact on drug discovery & development programs and research publications in scientific journals.

ROLE RESPONSIBILITIES

• Develop innovative strategies for understanding role of cell signaling and/or cell cycle targets in cancer progression, drug resistance and immune modulation

• Lead preclinical research for oncology assets to advance mechanism of action studies, develop patient responder hypotheses, elucidate mechanisms of resistance, and identify rational drug combinations

• Provide scientific leadership and serve as biology lead for post-candidate programs in cross functional Global Product Teams to support asset clinical development

• Interface with groups of discovery biology, discovery technologies, computational biology, in vivo pharmacology, drug pharmacokinetics, and drug safety to design experiments and interpret datasets to advance pipeline projects

• Work collaboratively with translational oncology to integrate complex preclinical and clinical datasets and support reverse translation efforts

• Actively contribute to the regulatory strategy for projects and may author key regulatory submission documents (IND, IB etc.) needed to support candidate development.

• Proactively seek out new information in the literature and incorporate the learnings to progress preclinical research and MOA understanding of the target.

• Present research findings and share learnings at research project team meetings, post-CAN biology meetings and other broader research forums

• Contribute to building a culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base and cancer biology expertise; take a proactive role in personal growth and scientific development.

QUALIFICATIONS

Basic Qualifications

• PhD or MD/PhD in Molecular or Cellular Biology, Genetics, Pharmacology (or a comparable biological science) with 7+ years of relevant postdoctoral experience in an pharmaceutical/biotech or academic environment. Prior industry experience is preferred.

• Expertise in cell signaling and/or cell cycle biology as evidenced by publication in peer-reviewed journals

• Preference for candidates with a strong track record in oncology translational research and/or drug discovery in the field of cell cycle/cell signaling pathways

• Strong ability to multi-task, lead biology research activities across multiple programs in collaboration with different partner lines

• Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

Preferred Qualifications

• Experience in leading preclinical translational oncology research and working with cross-functional clinical development teams

• Knowledge of other areas of cancer biology and relevant clinical landscape including oncogenic signaling, DNA repair, cancer epigenetics and ADC biology

• Experience supporting regulatory submissions and authoring of IND study reports

• Managerial experience, preferably in industry setting

Relocation support available

Work Location Assignment:On Premise

The annual base salary for this position ranges from $117,300.00 to $195,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development