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ROLE SUMMARY

Pfizer's Oncology Research Unit (ORU) in La Jolla, California, is seeking a self-motivated and collaborative Scientist (non-PhD) to join the Post-CAN research group focused on translating basic discoveries in the field of cancer cell biology into novel therapeutics.

The Scientist will participate in conducting preclinical research on our clinical and pre-clinical drug programs with a focus on oncogenic signaling and cell cycle assets. The Scientist will work as a member of the Cancer Cell program team to support translational research efforts utilizing pharmacological and genetic approaches to investigate target mechanism of action, intrinsic and acquired resistance, patient stratification strategies and drug combinations. The candidate with serve as a technical and scientific expert in the lab and will work independently and in collaboration with other team members to design, execute and analyze/interpret experiments. The successful candidate will demonstrate a proven track record of scientific productivity and high-level of technical competence in a wide range of in vitro pharmacology and cellular/molecular biology techniques.

ROLE RESPONSIBILITIES

• Work independently and as part of teams to design, execute, analyze/interpret, and refine experiments ranging from in vitro pharmacology, biomarker assay development, functional cellular assays, molecular biology and in vivo tissue sample analysis

• Apply genetic and pharmacologic approaches including CRISPR, RNAi, antibodies, small molecules etc. to modulate targets in vitro and assess functional impact on cancer initiation and progression

• Execute experiments to advance mechanism of action studies, evaluate patient responder hypotheses, elucidate mechanisms of resistance, and assess rational drug combinations

• Conduct cell-based assays across various technology platforms - qPCR, immunoprecipitation, FACS, immunofluorescence, western blotting, ELISA, high content screening, etc.

• Develop and apply complex in vitro assays for target validation and secondary pharmacology: spheroid models, colony forming assays, 3D co-culture systems, organoid systems

• Collaborate with in vivo pharmacology group to support in vivo efficacy testing and assess target modulation in tumor tissues using supporting assays (ELISA, western blot, gene expression analysis of tissue lysates)

• Proactively seek out, embrace, and validate new technology/methods that can be incorporated into individual project(s) as well as the overall program

• Use electronic data capture/analysis tools such as Excel, GraphPad, Biobook, Spotfire and PowerPoint for experimental documentation and data analysis/presentations

• Present research results and methodologies at weekly meetings with immediate supervisor, research project meetings, PCR group meetings and other forums.

• Contribute to building a culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base and cancer biology expertise; take a proactive role in personal growth and scientific development

QUALIFICATIONS

Basic Qualifications

• Bachelor's degree with 6+ or Master's degree with 4+ years of experience in Molecular or Cellular Biology, Biochemistry, Genetics/Genomics, Pharmacology, or related field in an academic or pharmaceutical/biotech environment

• A proven high-level of technical competence and extensive experience in a wide range of in vitro pharmacology and cellular/molecular biology techniques

• Preference for candidates with a strong track record in cancer drug discovery and/or translational research focusing on cell cycle or/and cell signaling

• Strong ability to multi-task, work efficiently and productively in a fast-paced, highly collaborative team environment

• Strong attention to detail and organizational skills; excellent communication skills

• Experience in use of CRISPR-based techniques for gene knockout, gene editing and working knowledge of pooled CRISPR -based screening approaches

Work Location Assignment: On Premise

The annual base salary for this position ranges from $74,900.00 to $124,800.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development