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ROLE SUMMARY

Senior Scientist (R04) - ADME/PBPK Modeling

The individual will be the ADME and PBPK modeling expert for the Pharmacokinetics, Dynamics & Metabolism (PDM) department. The individual partners with PDM portfolio representatives (PRs), scientific leaders, and crossline modelling scientists to address the ADME and PBPK modeling needs of the portfolio. The individual will be the technical expert for the department, while also influencing external scientific and regulatory practices through publication and other interactions.

ROLE RESPONSIBILITIES

• Apply technical and functional PDM expertise to direct or undertake physiologically-based pharmacokinetic (PBPK) modeling strategies, which support and achieve project goals from idea to proof-of-concept through drug registration (including NDA and global submissions), and post-market.

• Working across global lines with modeling and simulation scientists (e.g., Clinical Pharmacology, Pharmaceutical Sciences), taking scientific leadership for integrating predictions of drug ADME (absorption, distribution, metabolism, and elimination) as well as drug-drug interaction risk assessment.

• Contribute to authoring, review, and approval of modeling related research reports, nonclinical ADME summaries, and abstracts/manuscripts for internal or external publication. Present data internally and externally in meetings and conference proceedings.

• Proactively establish and grow effective partnerships externally as well as internally across multiple disciplines (e.g., Clinical Pharmacology, Pharmaceutical Sciences, Medicinal Chemistry, Computational Sciences, High Throughput Screening) to advance scientific innovation in the realm of ADME/PBPK modeling.

• Keep abreast of scientific/technological developments by participating in scientific meetings/seminars and through regular scientific review.

• Ensure adequacy, timeliness, and high quality of execution of modeling to meet scientific and regulatory requirements of the U.S. FDA, and Drug Regulatory Agencies worldwide.

• Mentor scientists in pharmacokinetic data analysis (e.g., noncompartmental analysis) and PBPK modeling

BASIC QUALIFICATIONS

• MS or PhD level education (or BS with 5 or more years) in a relevant field with industry experience in the scientific field.

• Experience working in matrix teams within and across technical/research line organizations, a collaborative problem solver.

• Strong leadership and interpersonal skills as well as a track record of enthusiasm to deliver results in a fast-paced environment.

• Highly effective written, presentation and verbal communication skills are essential.

• Proficiency in the use of Microsoft Office Suite of tools (Outlook, Word, Excel, etc.) and hands-on experience establishing IVIVE, computational ADME predictions, and data visualization tools.

PREFERRED QUALIFICATIONS

• Hands-on experience with ADME, PK, and physiologically-based (PBPK) modeling using tools such as Simcyp™, Phoenix WinNonlin™, Berkeley Madonna, NONMEM ® , R, and/or GastroPlus®.

• Broad understanding of ADME and in vitro drug metabolizing enzyme and transporter assays. Ability to integrate data from multiple sources into a rational understanding of drug disposition.

PHYSICAL/MENTAL REQUIREMENTS

Ability to perform complex mathematical calculations and its application in PK and PBPK data modeling. High-level integration of complex data in analyses.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Regulatory responses could be time-sensitive, which occasionally requires working extended hours in the evenings or on weekends.

Periodic travel will be required to other Pfizer sites (e.g., Cambridge, MA; La Jolla, CA) or to attend and present at scientific conferences.

Additional Information:

• Relocation support available

• Eligible for Employee Referral

• Work Location Assignment:On Premise

• Last Day to Apply: October 13, 2024

The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development

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