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Biogen Principal Associate Scientist, Research in Cambridge, Massachusetts

• Design, lead, and conduct in vivo mouse studies for pipeline programs.

• Coordinate with research cross-functional teams and organizations, including Translational Pathology, Preclinical Safety, Comparative Medicine, Neuromuscular Research Unit.

• Perform techniques and procedures to support in vivo studies, such as AAV injections, necropsy sessions, tissue collections and microdissections for downstream biochemical analysis, including mouse CNS subregions and dorsal root ganglia.

• Conduct data analysis and organize meetings for data review.

• Write, present, and publish data an original research articles.

• Perform biochemical and molecular biology assays to enable PK PD analysis for the gene therapy candidate drugs, including genomic DNA and RNA isolation, qPCR, ELISA and western blotting.

• Use computational tools and programming languages to conduct in depth analysis in large next generation sequencing datasets.

• Represent home function group for Biogen and CRADL IACUC protocol management.

• Work closely with scientists and IACUC to enable the use of rodents for drug candidate experimentation.

• Serve as SME for multiple gene therapy in vivo studies and provide training and guidance for new colleagues in conducting in vivo studies.

• Telecommuting permitted up to 20%.

Minimum Requirements:

The position requires a Master's degree (or foreign equivalent) in Neuroscience, Cell Biology, Molecular Biology, or related field and 3 years of experience in the job offered or a Scientist-related occupation.

Experience must include:

3 years of experience in each of the following:

  • Biotechnology or pharmaceutical industry experience.

  • Working with rodent disease models, including demonstrable experience with each of the following: handling, intracerebroventricular injection, intrathecal injection, CNS and PNS tissue harvest, electrophysiological recording, and behavioral testing.

  • Utilizing biochemical and molecular biological techniques, including demonstrable experience with each of the following: DNA and RNA isolation, qPCR, ELISA or MSD, and immunoblotting.

  • Utilizing appropriate scientific software to analyze experimental datasets, including demonstrable experience with each of the following: MS Office, GraphPad Prism, R, and snRNAseq analysis.

  • Knowledge of recombinant adeno-associated virus engineering and development.

  • Knowledge of drug discovery and development.

  • Knowledge of basic neurobiology and neurodegenerative diseases.


1 year of experience with the following:

Developing protocols to isolate single nuclei from CNS or PNS tissues

All your information will be kept confidential according to EEO guidelines.

Why Biogen?

Our mission to find therapies for neurological and rare diseases is a unique focus within our industry and this shared purpose is what connects us as a team. We work together to overcome obstacles and to follow the science. We are resilient as we strive to make an impact on our patients’ lives and on changing the course of medicine. Together, we pioneer. Together, we thrive.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.