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Pfizer Evidence Generation Program Director, Oncology & Rare Disease in Cambridge, Massachusetts


This position will assume a key leadership role within the Pfizer organization, serving as Program Director in the Evidence Generation Portfolio Operations and Project Management (POPM) group. It will reside in the newly formed Evidence Generation Platform, which is responsible for establishing scientific global leadership and stature through the generation of integrated, end-to-end, observational real-world evidence serving all therapeutic areas. The Platform aims to:

  • Enhance Pfizer's ability to determine unmet medical needs;

  • support current Product Development programs including finding alternatives and accelerated licensure pathways for new indications through the use of Real World Data (RWD), Real World Insights (RWI) and Real World Evidence (RWE);

  • inform clinical practice on appropriate prescription and use of Pfizer products;

  • in collaboration with PHI, strengthen the value evidence package for payers and access/policy decision-makers;

  • support measurement of short- and long-term impact of Pfizer products to both patients and populations; support competitive differentiation.

The Program Director provides operational expertise and project management leadership for several RWE initiatives of high complexity across multiple categories. By developing and implementing best practices in project management and process improvements, they will help establish Pfizer as an industry leader in generation and use of Real World Evidence for drug development. Critical success factors include excellent communication skills, industry savvy, effective collaboration across Pfizer enterprise, mastery of complex financial tracking, and understanding of how to drive sound portfolio decision analyses and planning.

The Program Director leads PM activities to deliver cost-effective, timely, and high-quality Real World Evidence, Real World Data and Real World Insights across their categories in scope, encompassing products' lifecycle management from Proof of Concept (POC) through loss of exclusivity (LOE). The Program Director will ensure delivery of work products within the agreed upon budgets/resources/timelines; participate in Op Planning activities for categories in scope, expertly track budgetary sourcing/spending; maintain high quality, continuous portfolio data availability and analytics; play a key role in governance activities such as PRC, and may also assist with other duties as assigned.

Consequently, this is a position for a skilled motivated individual who enjoys the challenge and excitement of identifying and deploying best practices in PM to ensure success of the team and Pfizer.


Key strategic deliverables include:

  • Responsible and accountable for developing and implementing industry-leading project management processes for utilization of RWE across programs within categories in scope.

  • Builds bridges across category stakeholders as a key player in the successful development and integration of the Evidence Generation Platform to achieve a One Pfizer vision for RWE/RWD/RWI generation.

  • Leads and ensures accurate and timely budget management across all sources of funding for RWE projects. Liaises with Finance to align on priorities and resource allocation, and with business partners to align on the business/operational strategy and priorities for the Evidence Generation platform.

  • Leverages portfolio decision analyses skill sets to assist assets and regions with creating business cases for investment in RWE.

  • Contributes to design and execution of a communication strategy, including publications in peer-reviewed journals.

Operational Delivery

  • Provides accurate milestones, timelines and budgets management for RWE projects within categories in scope to ensure delivery against goals (cost, speed, quality).

  • Manages governance processes such as Evidence Generation Portfolio Review Committee (PRC) for categories in scope.

  • Coordinates prioritization of portfolio and resource deployment for programs using RWE in partnership with RWE Scientific Leads and RWE Clinical Asset Leads.

  • Develops and oversees process frameworks for RWE category teams to utilize in managing Evidence Generation deliverables aligned to program strategic plans. (May include Medical Plans, IEP, DP3, Medicine Development Plans, E2E, Partner Line Service Agreements, Digital, etc).

  • Maintains portfolio systems and capabilities to support Evidence Generation scope in seamless collaboration with the CMAO, Global Medical Excellence and Innovation (GME&I) and Quality/Compliance.

  • Participates in Op Planning efforts for RWE Evidence Generation Platform across categories in scope.

Partner Line and Stakeholder Management

  • Responsible for developing and fostering strong working relationship with key Pfizer partners across categories and regions in scope. Identify and implement process improvements to ensure alignment with the evolving Pfizer operational and financial governance processes.

  • Responsible for integrated portfolio reporting and analyses to support the requirements of Evidence Generation. Proactively streamlines the processes for resource planning and portfolio prioritization within their category.

  • Coordinates effectively with GPD Project & Portfolio Management as well as other relevant PM organization across the enterprise.

  • Represents the team at business venues, meeting, conferences, interactions with external and internal stakeholders.


  • Individual contributor. May have the opportunity to build a team and manage others as the Evidence Generation group expands.

  • Leads teams in a matrix-based organization; develops and implements PM tools enabling consistent execution of RWE projects for relevant categories to drive decision making that maximizes business value culminating in high quality strategic and operational delivery within budget constraints.

Talent Development and Performance

  • Aligns and motivates colleagues behind the Evidence Generation Vision.

  • Fosters leadership and continuous improvement methodologies, leveraging innovative ideas to develop colleagues' skills and ensure the EvGen group can become/stay the best in the industry.

  • Helps identify and recruit key talent and retain them by contributing to building a vibrant culture within the Evidence Generation group.


Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

  • Bachelor's degree in one of the disciplines related to drug development or business management.

  • Strong financial acumen, experience managing multi-line complex budgets, including tracking of finances and FTEs.

  • Excellent communicator who can comfortably present to senior leadership.

  • In-depth knowledge of the pharmaceutical industry, with at least 10 years of experience working in the pharmaceutical industry.

  • Proven track record in a project management leadership role with at least 7 years of experience managing multiple, highly complex projects and portfolio governance.


  • Advanced scientific (MS, PhD, MD) or business (MBA) degree is preferred.

  • Experience in Oncology and/or Rare Diseases a plus.

  • Formal training or certification in project management methodologies (PMP, six sigma, Agile).

  • Strong contributor to strategic planning with leadership teams and track record of implementation success.

  • Demonstrated success negotiating in a highly matrix-based organization.

  • Strong track record meeting personal and team goals.

  • Proven record of implementing portfolio management practices and process improvements.

  • Understands R&D portfolio pipeline and in-line asset strategic objectives to effectively ensure tactical implementation.

  • Clear understanding of resource management at team and portfolio level.

  • Hands-on experience in governance management and portfolio reporting.

  • Demonstrated understanding of stakeholder risk management and mitigation strategies to simulate the likely obstacles to project progression.

  • Experience utilizing project management software programs such as MS Project, Planisware, Jira, etc

  • Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.


Travel of 5-10%, depending on budgets


  • Last Date to Apply for Job: June 6, 2023

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

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