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Children's Hospital Boston Research Assistant I / Chemistry in Boston, Massachusetts

61250BRTitle:Research Assistant I / ChemistryDepartment:Critical CareAutoReqId:61250BRStatus:Full-TimeStandard Hours per Week:40 Job Category:ResearchJob Posting Description:At Boston Children’s Hospital, the quality of our care – and our inclusive hospital working environment – lies in the diversity of our people. With patients from local communities and 160 countries around the world, we’re committed to reflecting the spectrum of their cultures, while opening doors of opportunity for our team. Here, different talents pursue common goals. Voices are heard and ideas are shared. Join us, and discover how your unique contributions can change lives. Yours included.

We are looking for a research assistant excited about translational research to join Professor Robert Langer and Daniel Anderson’s laboratory at the Koch Institute of Integrative Cancer Research, MIT to support a research project on developing glucose-binding elements for glucose-responsive insulin. This project is funded by a grant through Boston Children’s Hospital. This is a highly interdisciplinary project at the intersection of synthetic organic chemistry, bioconjugate chemistry, peptide engineering; and involves multiple collaborations. The role will involve running in vitro/ in vivo assays for evaluating compounds. In addition, the person will be expected to maintain accurate laboratory records, and stock laboratory supplies. This is a great opportunity for engineers interested in gaining research experience in an interdisciplinary area combining engineering with translational research before applying for graduate/medical school.

The candidate will work directly under the supervision of Dr. Arnab Rudra, and interested applicants should email Dr. Rudra at arnab.rudra@childrens.harvard.edu with a CV and a brief description of their interests.

Principal Duties and Responsibilities

  • Perform chemical synthesis of key intermediates in 2-3 steps, scale up, and purify using normal and reverse phase liquid chromatography. Records results accurately and troubleshoots procedures.

  • Maintain and perform in vitro assays (in vitro radioligand binding assays).

  • Performs analysis using mass spectrometric data for quantification of various peptides or key intermediates.

  • Attends courses in safety procedures for handling, storage and disposal of biohazardous, flammable, corrosive and toxic materials. Carries out all laboratory activities in compliance with applicable regulations and protocols.

  • Conducts literature searches and reviews, compiling information for journals and suggesting uses for new techniques to the P.I. Attends courses, lectures and conferences to further own knowledge of research and laboratory techniques, consulting with other researchers to exchange information.

  • Contributes to the teamwork within and between departments and organizations.

    Minimum Knowledge and Skills required by the Job

  • BS/MS degree in chemistry/ biochemistry/ or any closely related field, and previous lab experience.

  • Staff will be trained to use the relevant techniques in NMR, mass spectrometry but previous experience with some of the following techniques would be advantageous;

    - in vitro binding assays (radioligand based, other biophysical techniques) - purification of small molecule intermediates
  • Ability to resolve problems that require the use of basic scientific, mathematical, or technical principles.

  • Ability to exchange information on factual matters, schedule appointments and keep accurate records.

Please note: During a public health emergency, individuals in this role may be expected to take on additional duties to respond to organizational needs.

BCH offers competitive compensation.

Boston Children’s Hospital is an Equal Opportunity / Affirmative Action Employer. Qualified applicants will receive consideration for employment without regard to their race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status or disability

Office/Site Location:BostonRegular, Temporary, Per Diem:Regular